منابع مشابه
Packing in protein cores.
Proteins are biological polymers that underlie all cellular functions. The first high-resolution protein structures were determined by x-ray crystallography in the 1960s. Since then, there has been continued interest in understanding and predicting protein structure and stability. It is well-established that a large contribution to protein stability originates from the sequestration from solven...
متن کاملRandom close packing in protein cores.
Shortly after the determination of the first protein x-ray crystal structures, researchers analyzed their cores and reported packing fractions ϕ ≈ 0.75, a value that is similar to close packing of equal-sized spheres. A limitation of these analyses was the use of extended atom models, rather than the more physically accurate explicit hydrogen model. The validity of the explicit hydrogen model w...
متن کاملPacking is a key selection factor in the evolution of protein hydrophobic cores.
The energy derived from optimized van der Waals interactions in closely packed, folded proteins has been proposed to be of similar energetic magnitude to hydrophobicity in stabilizing the native state. If packing is this energetically important, it should influence the evolution of protein core sequences. To test this hypothesis, the occurrence of various amino acid side chains in the major hyd...
متن کاملPolarizable protein packing
To incorporate protein polarization effects within a protein combinatorial optimization framework, we decompose the polarizable force field AMOEBA into low order terms. Including terms up to the third-order provides a fair approximation to the full energy while maintaining tractability. We represent the polarizable packing problem for protein G as a hypergraph and solve for optimal rotamers wit...
متن کاملPacking of Myelin Protein Zero
Senyon Choe P 0 and also by its association with apposing plasma membrane (Filbin et al., 1990). The self-adhesive prop-Structural Biology Laboratory erty of P0ex is essential in maintaining compact mem-The Salk Institute for Biological Studies brane adhesion. Consequently, mutations in P0 can lead La Jolla, California 92037 to various hypo-and dysmyelinating diseases. The detailed molecular st...
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ژورنال
عنوان ژورنال: Journal of Physics: Condensed Matter
سال: 2017
ISSN: 0953-8984,1361-648X
DOI: 10.1088/1361-648x/aa75c2